Renal Function, Erythropoietin, and Anemia of Older Persons

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Anemia in older persons.

Anemia in older persons is commonly overlooked despite mounting evidence that low hemoglobin levels are a significant marker of physiologic decline. Using the World Health Organization definition of anemia (hemoglobin level less than 13 g per dL [130 g per L] in men and less than 12 g per dL [120 g per L] in women), more than 10 percent of persons older than 65 years are anemic. The prevalence ...

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Serum erythropoietin concentration in chronic renal failure: relationship to degree of anemia and excretory renal function.

By use of the fetal mouse liver cell assay, serum erythropoietin (SEp) concentration was measured in 135 patients at various stages of chronic renal failure and in 59 healthy subjects. In patients with creatinine clearances (CCr) ranging from 2 to 40 ml/min/1.73 sq m, endocrine renal function was found to deteriorate in parallel to excretory renal function. The known negative correlation betwee...

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Role of Erythropoietin in Renal Anemia Therapy

Renal anemia is a common complication of chronic renal failure caused by erythropoietin deficiency; targeting erythropoietin is a common approach to renal anemia treatment. This paper describes the role of erythropoietin and others drugs in renal anemia treatment, as well as the cause of erythropoietin resistance.

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The definition of anemia in older persons.

CONTEXT Whether hemoglobin concentrations defined as anemia by the World Health Organization (WHO) are associated with increased mortality in older persons is not known. OBJECTIVE To investigate the association between hemoglobin concentration and cause-specific mortality in older persons. DESIGN Community-based study conducted from 1986 to 1996 (follow-up period, 10 years). SETTING Leide...

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Proinflammatory state, hepcidin, and anemia in older persons.

In patients with overt inflammatory diseases, up-regulated hepcidin impairs iron absorption and macrophage release, causing anemia. Whether the mild proinflammatory state of aging is associated with increased hepcidin is unknown. We characterized the relationships between urinary hepcidin, iron status, anemia, and inflammation in 582 patients 65 years or older participating in the InCHIANTI (In...

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ژورنال

عنوان ژورنال: Archives of Internal Medicine

سال: 2005

ISSN: 0003-9926

DOI: 10.1001/archinte.165.19.2222